Place of Origin: | China |
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Brand Name: | HNB |
Certification: | ISO |
Model Number: | Genipin |
Minimum Order Quantity: | 1KG |
Price: | Negotiable |
Packaging Details: | Aluminum foil bag |
Delivery Time: | Usually3-5days |
Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram,Alibaba Assurance Order |
Supply Ability: | 5000kg/Month |
CAS: | 6902-77-8 | Mf: | C11H14O5 |
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MW: | 226.23 | Specification: | 98% |
EINECS: | 300-006-4 | Appearance: | White Crystalline Powder |
Sample: | Available | ||
High Light: | 98% Genipin Powder,Pharmaceutical Grade Genipin Powder,API Pharmaceutical 6902-77-8 |
CAS 6902-77-8 Pharmaceutical Grade 98% Genipin Powder Natural Bio-Crosslinking Agents
Product name |
Genipin |
Appearance |
White crystalline powder |
CAS |
6902-77-8 |
MF |
C11H14O5 |
Purity |
99% |
Storage |
Keep in cool dry place. |
The Introductction of Genipin
Genipin is white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from gardenia fruit.
Genipin is a natural cross-linking agent extracted from the fruit of Gardenia jasminoides. It can prevent lipid peroxidation and nitric oxide production. Genipin protects hippocampal neurons from Alzheimer′s disease β-amyloid toxicity. Has anti-inflammatory and anti-angiogenic effects. Involved in drug delivery system.
Genipin is generally prepared by extracting genipin glycosides from gardenia, then hydrolyzing them with β-glucosidase, followed by extraction with ethe*, vacuum concentration, and recrystallization, or it can be prepared by microbial transformation.
The Application & Function of Genipin
Genipin has a variety of biological activities including protein modulation, anti-tumor, anti-inflammatory, immunosuppressive, anti-thrombotic and hippocampal neuron protection.Genipin is also used in type 2 diabetes research.
Genipin is an anticholinergic inhibitor of gastric function, anticancer and hepatoprotective.
Genipin increases mitochondrial membrane potential, increased ATP levels, closed KATP channels, and stimulated insulin secretion in pancreatic islet cells. Genipin causes suppression of insulin signal transduction through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate-1 (IRS-1), thus impairing insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Genipin activates IRS-1, PI3-K, and downstream signaling pathway and increases concentrations of calcium, resulting in glucose transporter 4 (GLUT4) translocation and glucose uptake increase in C2C12 myotubes. Cytochrome c content increases significantly in the cytosol of Genipin-treated FaO cells. Activation of caspase-3 and caspase-7 is ultimately responsible for Genipin-induced apoptotic process in hepatoma cells. ROS level notably increases in Hep3B cells treated with 200 μM Genipin.
Other Name of Genipin
enipin
Genipin
GENIPIN
(+)-Genipin
The COA of Genipin
ITEMS OF ANALYSIS | SPECIFICATIONS | RESULT |
Appearance | White crystalline powder | Complies |
Assay(HPLC) | 98.0%~101.0%(on dried basis) | 99.8% |
Identification | HPLC | Complies |
IR | Complies | |
Solubility | Complies | Complies |
Loss on drying | ≤ 0.5% | 0.18% |
Residue on ignition | ≤ 0.1% | 0.03% |
Heavy Metals | ≤ 20ppm | <20ppm |
Conclusion | Complies With USP43 standard |
6902-77-8